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Related Experiment Videos

Cimetidine dynamics after repeated intravenous injection.

S Pancorbo, M P Bubrick, T W Chin

    Clinical Pharmacology and Therapeutics
    |January 1, 1984
    PubMed
    Summary

    Cimetidine effectively prevents stress ulcers in trauma patients. Higher drug concentrations in both serum and the stomach correlate with increased gastric pH, indicating therapeutic success.

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    The conformation of acetylcholine at its target site in the membrane-embedded nicotinic acetylcholine receptor.

    Proceedings of the National Academy of Sciences of the United States of America·2007

    Area of Science:

    • Pharmacokinetics and Pharmacodynamics
    • Critical Care Medicine
    • Gastroenterology

    Background:

    • Stress ulceration is a significant risk in multiple-trauma patients.
    • Prophylactic use of cimetidine is common in intensive care settings.

    Purpose of the Study:

    • To investigate the pharmacokinetics and pharmacodynamics of cimetidine in multiple-trauma patients.
    • To correlate cimetidine concentrations with gastric pH and therapeutic efficacy.

    Main Methods:

    • Studied six multiple-trauma patients receiving intravenous cimetidine (300-600 mg every 6 hr).
    • Measured serum and intragastric cimetidine concentrations.
    • Monitored gastric pH over a mean duration of 7.8 days.

    Main Results:

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    • A positive correlation was observed between cimetidine serum concentration and gastric pH.
    • Intragastric cimetidine concentration showed a stronger correlation with gastric pH.
    • Therapeutic efficacy (gastric pH > 4) was significantly associated with serum concentrations over 1 mcg/ml and intragastric concentrations above 2 mcg/ml.

    Conclusions:

    • Cimetidine pharmacokinetics and intragastric concentrations are critical for achieving therapeutic gastric pH in trauma patients.
    • Maintaining adequate cimetidine levels is essential for effective stress ulcer prophylaxis.