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Upper gastrointestinal polyps in Gardner's syndrome.
Gastroenterology
|February 1, 1984
Summary
Upper gastrointestinal polyps are common in Gardner's syndrome patients in the US. This study found gastric, duodenal, and ileal polyps, indicating a pleiotropic manifestation of the genetic defect.
Area of Science:
- Gastroenterology
- Genetics
- Oncology
Background:
- Upper gastrointestinal polyps are rarely associated with Gardner's syndrome (GS) and familial polyposis coli (FPC).
- Recent Japanese studies report high prevalence of gastric and duodenal polyps in GS/FPC patients.
Purpose of the Study:
- To investigate the occurrence of upper gastrointestinal polyps in US-based Gardner's syndrome patients.
- To determine if upper GI polyps are a common manifestation of GS in the United States.
Main Methods:
- Endoscopic examination of 11 affected members of a Gardner's syndrome kindred.
- Histological analysis of polyps from the stomach, duodenum, and terminal ileum.
Main Results:
- Six patients had gastric polyps (fundic gland hyperplasia in 5).
- Eight patients had duodenal polyps (all adenomas).
- Nine patients had ileal polyps (adenomas or lymphoid aggregates).
Conclusions:
- Upper gastrointestinal polyps are a frequent finding in US Gardner's syndrome patients.
- These findings suggest upper GI polyps are a common pleiotropic manifestation of the genetic defect in Gardner's syndrome.
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