Idiopathic intestinal pseudo-obstruction in a family

Related Experiment Video

Updated: Aug 13, 2026

A Mouse Model of Intestinal Partial Obstruction
07:33

A Mouse Model of Intestinal Partial Obstruction

Published on: March 5, 2018

H S Teixidor, M A Heneghan

    Gastrointestinal Radiology
    |April 15, 1978
    PubMed

    Insights

    Idiopathic intestinal pseudo-obstruction presents with varied symptoms. This family study suggests it may not originate in the gastrointestinal tract, with its cause remaining unknown.

    Area of Science:

    • Gastroenterology
    • Medical Genetics

    Background:

    • Idiopathic intestinal pseudo-obstruction (IIPO) is a rare condition mimicking bowel obstruction without a mechanical cause.
    • Diagnosis relies on excluding other known causes, presenting diagnostic challenges.

    Observation:

    • A patient with severe IIPO symptoms is described.
    • Three family members exhibit milder, similar symptoms, indicating a potential genetic component.
    • Associated megacystis (enlarged bladder) is noted in the family and literature cases.

    Findings:

    • The wide spectrum of clinical and radiological presentations complicates IIPO diagnosis.
    • A high incidence of megacystis suggests a systemic or neurological origin rather than a primary gastrointestinal issue.

    Implications:

    • IIPO may stem from a non-gastrointestinal etiology, possibly neurological or systemic.
    • Further research into the underlying cause of IIPO and its association with megacystis is warranted.

    More Related Videos

    Chronic Salmonella Infection Induced Intestinal Fibrosis08:40

    Chronic Salmonella Infection Induced Intestinal Fibrosis

    Published on: September 22, 2019

    Postoperative Ileus Murine Model04:26

    Postoperative Ileus Murine Model

    Published on: July 12, 2024

    Related Concept Videos

    Pleiotropy01:33

    Pleiotropy

    Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
    Inflammatory Bowel Disease V: Surgical Management01:21

    Inflammatory Bowel Disease V: Surgical Management

    Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
    Here are some common surgical interventions for IBD:
    Pyloric Obstruction01:11

    Pyloric Obstruction

    Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...
    Intestinal Obstruction I: Introduction01:29

    Intestinal Obstruction I: Introduction

    Intestinal obstruction is a partial or complete blockage of the small or large intestine that disrupts the normal flow of intestinal contents through the lumen. This interruption impairs digestion, absorption, and fluid balance, and may lead to serious complications if not treated promptly.Mechanical ObstructionMechanical obstruction occurs when a physical blockage prevents intestinal contents from passing, arising from within the lumen or the bowel wall, or from external compression.Adhesions,...
    Intestinal Obstruction II: Pathophysiology01:07

    Intestinal Obstruction II: Pathophysiology

    Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...
    Diverticular Disease of the Colon01:27

    Diverticular Disease of the Colon

    Diverticular disease involves the formation of diverticula—small sac-like outpouchings of the colonic wall—and their complications. It most commonly affects the sigmoid colon due to higher intraluminal pressure and structural vulnerability. It results from structural weakness and increased pressure in the colon, producing pseudodiverticula that may remain silent or progress to inflammation and serious complications.Structure of DiverticulaIn diverticulosis, these outpouchings are...