Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Isolated liver damage in chemical workers.

M Døssing, L Ranek

    British Journal of Industrial Medicine
    |February 1, 1984
    PubMed
    Summary

    Chemical plant workers experienced jaundice and liver cell necrosis due to workplace chemical exposure. Relapse occurred upon re-exposure, suggesting a synergistic hepatotoxic reaction, though the specific chemical cause remains unidentified.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of CT screening on smoking habits at 1-year follow-up in the Danish Lung Cancer Screening Trial (DLCST).

    Thorax·2008
    Same author

    Unchanged acetylation of isoniazid by alcohol intake.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2004
    Same author

    [The epidemic (of smoking) no one dares to see].

    Ugeskrift for laeger·2001
    Same author

    [Views on smoking as a risk factor in the development of diseases as seen by Birgit H. Pettersson].

    Ugeskrift for laeger·2001
    Same author

    [Cigarettes are and remain the great killer].

    Ugeskrift for laeger·2001
    Same author

    [Screening for lung cancer].

    Ugeskrift for laeger·2000

    Area of Science:

    • Occupational Medicine
    • Hepatology
    • Toxicology

    Background:

    • Three chemical plant workers presented with jaundice after 2-4 months of employment.
    • Liver biopsies revealed severe centrilobular, hemorrhagic liver cell necrosis.

    Purpose of the Study:

    • To investigate the cause of acute liver injury in chemical plant workers.
    • To identify potential hepatotoxic agents responsible for the observed liver damage.

    Main Methods:

    • Clinical case study of three affected workers.
    • Analysis of occupational exposures including carbon disulfide, isopropanol, toluene, and acrylonitrile.
    • Liver biopsy and histopathological examination.
    • Monitoring of clinical and biochemical markers of liver function.

    Main Results:

    • All workers developed jaundice and liver necrosis, which resolved over 6-18 months.
    • No extrahepatic organ damage was observed.
    • One worker who returned to the plant experienced a relapse of liver damage.

    Conclusions:

    • Workplace chemical exposure at the plant is strongly suspected as the cause of liver injury.
    • A synergistic hepatotoxic reaction, possibly mediated by the hepatic microsomal enzyme system, is hypothesized.
    • The specific causative chemical agent could not be identified due to multiple exposures.

    Related Experiment Videos