[Gluconeogenesis during therapy of experimental tumors with hydrazine sulfate]

Experiments in vivo were made to examine the action of hydrazine sulfate on the gluconeogenesis in the liver and kidneys of rats with Zajdela's hepatoma and mice with lymphoma NK/Ly. The intensity of the gluconeogenesis in the liver descended and in the kidneys increased. These alterations did not affect blood glucose content in the test animals. The data obtained do not support the hypothesis that the mechanism of hydrazine sulfate action by an abrupt depression of the gluconeogenesis during malignant growth is the sole mechanism.