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Related Experiment Videos

Plasma cortisol levels in paediatric anaesthesia.

H Obara, D Sugiyama, N Maekawa

    Canadian Anaesthetists' Society Journal
    |January 1, 1984
    PubMed
    Summary

    Plasma cortisol levels in neonates did not change significantly during anesthesia. In infants, anesthesia increased cortisol, but halothane suppressed this rise.

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    Area of Science:

    • Anesthesiology
    • Pediatric Endocrinology
    • Surgical Care

    Background:

    • Plasma cortisol levels are a key indicator of the stress response in infants and neonates.
    • Understanding how anesthesia affects the hypothalamic-pituitary-adrenal (HPA) axis is crucial for pediatric surgical care.

    Purpose of the Study:

    • To investigate the impact of general anesthesia on plasma cortisol levels in neonates and infants.
    • To compare the effects of anesthesia with and without halothane on cortisol response in infants.

    Main Methods:

    • Measurement of plasma cortisol levels during surgery in 7 neonates (≤10 days old).
    • Measurement of plasma cortisol levels in 14 infants (3-11 months old) divided into two anesthesia groups: Group I (oxygen, nitrous oxide, muscle relaxant) and Group II (oxygen, nitrous oxide, halothane, muscle relaxant).

    Main Results:

    • No statistically significant changes in mean plasma cortisol levels were observed in neonates during anesthesia.
    • In both infant groups, mean plasma cortisol levels increased during anesthesia.
    • The initial rise in plasma cortisol levels was suppressed in infants who received halothane (Group II) compared to those who did not (Group I).

    Conclusions:

    • Neonates exhibit a stable plasma cortisol response to anesthesia.
    • General anesthesia stimulates cortisol release in infants, indicating a stress response.
    • Halothane administration during general anesthesia can attenuate the cortisol response in infants.

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