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Necrotizing vasculitis from radiographic contrast media
Journal of the American Academy of Dermatology
|January 1, 1984
Summary
Radiocontrast media can cause necrotizing vasculitis and nephritis. Pre-injection with xylocaine and epinephrine may protect skin from these adverse reactions, suggesting a potential protective mechanism.
Area of Science:
- Nephrology
- Dermatology
- Radiology
Background:
- Adverse reactions to radiocontrast media can include systemic effects.
- Cutaneous necrotizing vasculitis and nephritis are severe potential complications.
Observation:
- Two patients developed vasculitis and nephritis post-intravascular radiocontrast injection.
- One patient showed spared skin in an area pre-treated with xylocaine and epinephrine.
Findings:
- The study presents cases of radiocontrast-induced vasculitis and nephritis.
- Pre-treatment with xylocaine and epinephrine appeared to prevent cutaneous vasculitis in one patient.
Implications:
- This observation suggests a potential protective role for xylocaine and epinephrine against radiocontrast-induced vasculitis.
- Further research into the mechanisms of radiocontrast hypersensitivity and potential prophylactic treatments is warranted.