Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dementia--Alzheimer type.

E Kokmen

    Mayo Clinic Proceedings
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Alzheimer's disease, a common cause of dementia, involves memory loss and cognitive decline. Research reveals neurobiological features like paired helical filaments and cholinergic neuron loss, but no cure exists yet.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Premorbid personality characteristics in Alzheimer's disease: an exploratory case-control study.

    Behavioural neurology·2014
    Same author

    Mild cognitive impairment in the oldest old.

    Neurology·2003
    Same author

    Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia.

    Neurology·2002
    Same author

    Prospective analysis of risk factors for nursing home placement of dementia patients.

    Neurology·2001
    Same author

    Mild cognitive impairment and Alzheimer disease: regional diffusivity of water.

    Radiology·2001
    Same author

    Rates of hippocampal atrophy correlate with change in clinical status in aging and AD.

    Neurology·2000
    Same journal

    37-Year-Old Woman With Jaundice.

    Mayo Clinic proceedings·2026
    Same journal

    34-Year-Old Woman With An Unidentified Overdose.

    Mayo Clinic proceedings·2026
    Same journal

    Use of Bronchoscopic Cryobiopsy in Evaluating Interstitial Lung Disease: Radiologic Predictors of Diagnostic Yield and Safety.

    Mayo Clinic proceedings·2026
    Same journal

    Advancing Pulmonary Fibrosis Care: Integrating Genomic Insights Into Clinical Practice.

    Mayo Clinic proceedings·2026
    Same journal

    RAAS Inhibition in the ICU: Stop, Continue, or Restart?

    Mayo Clinic proceedings·2026
    Same journal

    Chronic Kidney Disease-In the Limelight, July 2026.

    Mayo Clinic proceedings·2026
    See all related articles

    Area of Science:

    • Neurology
    • Neurobiology
    • Geriatrics

    Background:

    • Alzheimer's disease (AD) is a leading cause of progressive dementia, affecting memory, cognition, and intellect in at least 50% of affected patients.
    • Diagnosis relies on clinical evaluation and excluding other dementia causes.
    • Recent research has significantly advanced the understanding of AD's neurobiological underpinnings.

    Purpose of the Study:

    • To summarize current understanding of Alzheimer's disease neurobiology.
    • To highlight key pathological features and neurochemical changes associated with AD.
    • To underscore the lack of specific treatments and the need for patient and caregiver support.

    Main Methods:

    • Review of existing literature on Alzheimer's disease.
    • Analysis of neurobiological features, including electron microscopy of cortical neurons.

    Related Experiment Videos

  • Correlation of cholinergic system deficits with neuronal loss in specific brain structures.

    • Main Results:

    • Cortical neurons in AD patients exhibit paired helical filaments with a distinct electron microscopic structure.
    • These filaments are composed of proteins with unique characteristics.
    • A significant reduction in cortical cholinergic activity correlates with substantial loss of cholinergic neurons, particularly in the nucleus basalis of Meynert.

    Conclusions:

    • Alzheimer's disease is characterized by specific neuropathological findings, including paired helical filaments and cholinergic neuron degeneration.
    • Despite advances in understanding its neurobiology, no definitive treatment for Alzheimer's disease is currently available.
    • Comprehensive support systems are crucial for patients with Alzheimer's disease and their caregivers.