Control of the immune response to the EA-2.1 alloantigen of the mouse by the H-2 complex

The immunization of selected congenic strains and hybrids with the Ea-2.1 cellular alloantigen of the mouse shows that the anti-Ea-2.1 immune response is regulated by a gene or genes associated with the H-2 gene complex. It was earlier demonstrated that H-2r and H-2b were, respectively, responder and nonresponder haplotypes. In this report it is shown that the haplotypes H-2d and H-2g2 are also responder haplotypes, while H-2a, H-2k, H-2m, H-2p, H-2q, H-2awl and H-2u are nonresponder haplotypes. The responder H-2g2 and nonresponder H-2awl haplotypes are recombinant configurations that map the Ea-2.1 regulator gene, or genes, within or adjacent to the I-A subregion of the H-2 gene complex.