Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human skin aryl hydrocarbon hydroxylase.

M J Finnen, C M Lawrence, S Shuster

    The British Journal of Dermatology
    |March 1, 1984
    PubMed
    Summary

    Aryl hydrocarbon hydroxylase (AHH) activity in human skin is primarily found in the dermis. Coal tar application significantly increased AHH activity, regardless of psoriasis presence.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Long-term outcomes of imiquimod-treated lentigo maligna.

    Clinical and experimental dermatology·2019
    Same author

    Smectic viral capsids and the aneurysm instability.

    Journal of physics. Condensed matter : an Institute of Physics journal·2018
    Same author

    Use of Tisseel fibrin glue for a recurrent cheek haematoma after Mohs micrographic surgery.

    Clinical and experimental dermatology·2018
    Same author

    Dermoscopy prior to Mohs micrographic surgery does not improve tumour margin assessment and leads to fewer Mohs stages.

    The British journal of dermatology·2017
    Same author

    Diagnostic biopsy before Mohs micrographic surgery, frequency of change in diagnosis and impact on management.

    The British journal of dermatology·2015
    Same author

    Prospective study of formalin-fixed Mohs surgery and haematoxylin and eosin stains with control contralateral biopsies for lentigo maligna: 5-year follow-up results.

    The British journal of dermatology·2014

    Area of Science:

    • Dermatology
    • Biochemistry
    • Pharmacology

    Background:

    • Aryl hydrocarbon hydroxylase (AHH) is an enzyme involved in xenobiotic metabolism.
    • Understanding AHH activity in human skin is crucial for evaluating topical treatments.
    • Psoriasis is a chronic inflammatory skin condition with complexPathophysiology.

    Purpose of the Study:

    • To measure basal and induced Aryl hydrocarbon hydroxylase (AHH) activity in human skin.
    • To investigate the influence of psoriasis on AHH activity.
    • To determine the primary location of AHH activity within human skin layers.

    Main Methods:

    • Human skin biopsies from patients with and without psoriasis were analyzed.
    • AHH activity was measured using biochemical assays.
    • Enzyme activity was assessed before and after topical coal tar application.
    • Skin samples were separated into dermal and epidermal layers for localized analysis.

    Main Results:

    • Basal AHH activity exhibited a fivefold variation unrelated to patient demographics or clinical status.
    • Coal tar induced a two- to fivefold increase in AHH activity.
    • The induction of AHH activity by coal tar was consistent in both psoriatic and non-psoriatic skin.
    • AHH activity was found to be predominantly localized in the dermal layer of human skin.

    Conclusions:

    • Human skin AHH activity is primarily dermal.
    • Coal tar effectively induces AHH activity in human skin, irrespective of psoriasis.
    • AHH activity levels in human skin are not influenced by the presence or absence of psoriasis.

    Related Experiment Videos