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Related Experiment Videos

Circulating anticoagulant in CREST syndrome.

J Albert, J M Ekoe, M Cunningham

    British Journal of Rheumatology
    |February 1, 1984
    PubMed
    Summary

    A circulating anticoagulant was discovered in a patient with CREST syndrome, presenting with microangiopathic hemolytic anemia. This finding, alongside decreased clotting factors, highlights a potential complication of the syndrome.

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    Area of Science:

    • Hematology
    • Rheumatology
    • Internal Medicine

    Background:

    • CREST syndrome is a limited form of systemic sclerosis.
    • Microangiopathic hemolytic anemia can be an initial manifestation of CREST syndrome.

    Observation:

    • A patient diagnosed with CREST syndrome developed an abnormal coagulation screen.
    • Routine tests revealed a circulating anticoagulant and reduced levels of clotting factors, notably Factor VIII C.

    Findings:

    • The study identified a novel circulating anticoagulant in a CREST syndrome patient.
    • Coagulation factor deficiencies, particularly Factor VIII C, were observed concurrently.

    Implications:

    • This discovery suggests a potential link between CREST syndrome and acquired coagulation disorders.
    • Further research is warranted to understand the mechanisms and clinical significance of this anticoagulant.
    • Early detection of such coagulopathies may be crucial for managing patients with CREST syndrome.

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