[Biological effects of thrombin]

The influence of thrombin on functional and procoagulant activity of lymphocytes, monocytes, fibroblats and tumour cells, was studied. Thrombin enhanced phagocytic activity of monocytes and decreased the speed of their migration from the center of inflammation, accelerated growth of fibroblasts and tumour cells and increased synthesis of oxyprolin and glycosaminglycans by fibroblasts. Thrombin activated functional activity of cells, increased their procoagulant and fibrinolytic activity with the release of thromboplastic agents, plasminogen activator and plasmine-like enzyme. The data obtain suggest that thrombin is a biological irritant capable of changing cell reaction.