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[Cirrhosis induced by vitamin A]
Gastroenterologie Clinique Et Biologique
|February 1, 1984
Summary
Long-term high-dose vitamin A supplementation for psoriasis can lead to liver cirrhosis. This case highlights the rare but serious risk of vitamin A intoxication and its hepatic consequences.
Area of Science:
- Hepatology
- Toxicology
- Dermatology
Background:
- Psoriasis treatment often involves long-term medication use.
- Vitamin A is essential but can be toxic in excessive doses (hypervitaminosis A).
Observation:
- A 75-year-old woman with a 12-year history of high-dose vitamin A (250,000 IU/day) for psoriasis presented with newly detected hepatic cirrhosis.
- Clinical presentation and laboratory values were consistent with hypervitaminosis A.
Findings:
- Hepatic cirrhosis was diagnosed and attributed to chronic vitamin A intoxication.
- Histological examination revealed perisinusoidal fibrosis and characteristic findings in fat-storing cells.
Implications:
- This case underscores that hypervitaminosis A, though rare, is a potential cause of liver cirrhosis.
- Clinicians should monitor patients on long-term high-dose vitamin A therapy for potential hepatotoxicity.