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A fatal methamphetamine poisoning associated with hyperpyrexia.

T Kojima, I Une, M Yashiki

    Forensic Science International
    |January 1, 1984
    PubMed
    Summary

    A fatal methamphetamine overdose case highlights hyperpyrexia as a potential cause of death. High concentrations of methamphetamine and its metabolite, amphetamine, were found in tissues, indicating severe poisoning.

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    Area of Science:

    • Forensic Toxicology
    • Pharmacology

    Background:

    • Methamphetamine abuse is a significant public health concern.
    • Understanding the toxicokinetics and lethal mechanisms of methamphetamine is crucial for forensic investigations.

    Observation:

    • A 25-year-old female methamphetamine abuser died after ingesting a large dose (approximately 1.5 g) of methamphetamine hydrochloride intravenously.
    • Rigor mortis onset was rapid (1-2 hours post-mortem).
    • Rectal temperature 3-4 hours post-mortem was 38.4°C, with an estimated post-mortem core temperature exceeding 41°C at the time of death.

    Findings:

    • Chemical ionization mass fragmentography revealed high concentrations of methamphetamine and its metabolite, amphetamine, in various tissues.
    • Concentrations (μmol/100 g) included: blood (0.26/28.8), brain (0.64/68.2), liver (0.96/117.1), kidney (0.53/50.6), and stomach contents (1.49/1045).

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  • Significant amounts of methamphetamine hydrochloride (11.6 mg) were present in stomach contents.

    • Implications:

    • Hyperpyrexia (elevated body temperature) is suggested as a primary factor contributing to the fatality.
    • The distribution of methamphetamine and amphetamine provides insights into the drug's metabolism and systemic effects.
    • This case underscores the extreme toxicity of methamphetamine and the potential for rapid, fatal outcomes.