Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The EEG in obsessive-compulsive disorder.

M A Jenike, A W Brotman

    The Journal of Clinical Psychiatry
    |March 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Electroencephalogram (EEG) abnormalities in the temporal lobes were found in one third of patients with severe obsessive-compulsive disorder. Anti-seizure medication trials showed limited efficacy in improving symptoms.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Meta-analysis of association between obsessive-compulsive disorder and the 3' region of neuronal glutamate transporter gene SLC1A1.

    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics·2013
    Same author

    Genome-wide association study of obsessive-compulsive disorder.

    Molecular psychiatry·2012
    Same author

    A magnetic resonance imaging study of regional cortical volumes following stereotactic anterior cingulotomy.

    CNS spectrums·2006
    Same author

    Improvement in severe self-mutilation following limbic leucotomy: a series of 5 consecutive cases.

    The Journal of clinical psychiatry·2002
    Same author

    The Skin Picking Impact Scale (SPIS): scale development and psychometric analyses.

    Psychosomatics·2001
    Same author

    Cerebral metabolic correlates as potential predictors of response to anterior cingulotomy for obsessive compulsive disorder.

    Biological psychiatry·2001
    Same journal

    Major Depressive Disorder and PTSD Treatment Outcome in Interpersonal Psychotherapy and Prolonged Exposure.

    The Journal of clinical psychiatry·2026
    Same journal

    Psychiatrists and Medical Aid in Dying: Entering Uncharted Waters.

    The Journal of clinical psychiatry·2026
    Same journal

    Mind and Metabolism in Crisis: US Mortality Involving Obesity and Psychiatric Disorders-Trends, Disparities, and ARIMA Projections.

    The Journal of clinical psychiatry·2026
    Same journal

    Generative AI for the Clinical Psychopharmacologist: Is It Ready for Prime Time?

    The Journal of clinical psychiatry·2026
    Same journal

    Posttrauma Benzodiazepine Use and Subsequent PTSD: A Population-Wide Analysis Following Extreme Traumatic Exposure.

    The Journal of clinical psychiatry·2026
    Same journal

    The Challenges of PTSD Prevention: Placing Benzodiazepine Use in Context.

    The Journal of clinical psychiatry·2026
    See all related articles

    Area of Science:

    • Neuroscience
    • Psychiatry
    • Clinical Neurology

    Background:

    • Severe obsessive-compulsive disorder (OCD) is a debilitating mental health condition.
    • The neurobiological underpinnings of severe OCD are not fully understood.
    • Investigating potential links between neurological abnormalities and OCD severity is crucial.

    Purpose of the Study:

    • To explore the prevalence of electroencephalogram (EEG) abnormalities in patients with severe obsessive-compulsive disorder.
    • To assess the therapeutic potential of anti-seizure medication in this patient group.

    Main Methods:

    • A cohort of 12 patients diagnosed with severe obsessive-compulsive disorder was studied.
    • Electroencephalogram (EEG) recordings were performed to identify neurological abnormalities, particularly over the temporal lobes.

    Related Experiment Videos

  • Patients with identified EEG abnormalities received a trial of anti-seizure medication.

    • Main Results:

    • Approximately one third of the patients (4 out of 12) exhibited EEG abnormalities localized to the temporal lobes.
    • Out of the patients who received anti-seizure medication, only one individual showed improvement in OCD symptoms.
    • This suggests a limited response rate to anti-seizure medications in this specific subgroup.

    Conclusions:

    • Temporal lobe EEG abnormalities may be present in a subset of individuals with severe OCD.
    • Anti-seizure medications demonstrate minimal effectiveness for treating severe obsessive-compulsive disorder, even in the presence of EEG abnormalities.
    • Further research is warranted to elucidate the role of neurological factors in severe OCD and to identify more effective treatment strategies.