Mechanics of the human diaphragm during voluntary contraction: dynamics

We determined the static, isometric relationship between diaphragmatic EMG (Edi) and transdiaphragmatic pressure (Pdi) in man at specified abdominothoracic configurations, assessed with magnetometers. During inspiratory airflow, measurements of Edi and Pdi were taken as the respiratory system passed through the same configuration as obtained during the static isometric contractions, allowing a comparison of static and dynamic contractions of the diaphragm at a given length and curvature. When voluntary inspiratory maneuvers are performed with no associated outward displacement of the abdominal wall, or with slight inward displacement, the Pdi developed dynamically is the same as that developed statically at a given Edi. When outward movement of the abdominal wall occurs during inspiratory airflow, the Pdi developed dynamically depends on the rate of abdominal displacement, not on overall inspiratory airflow rate. We conclude that the velocity of shortening of the diaphragm increases directly as the rate of abdominal displacement. We construct a pressure-flow analogue of the force-velocity relationship for the diaphragm and discuss the functional implications of these observations in relation to spontaneous breathing.