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Systemic response to excretory urography. Work in progress.

H W Fischer, R W Katzberg, T W Morris

    Radiology
    |April 1, 1984
    PubMed
    Summary
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    Rapid intravenous injections of contrast media during excretory urography commonly cause transient hypotension. Some patients experienced significant blood pressure drops without obvious clinical symptoms.

    Area of Science:

    • Radiology
    • Cardiovascular Physiology
    • Pharmacology

    Background:

    • Excretory urography utilizes contrast media for visualizing the genitourinary tract.
    • Systemic hemodynamic responses to intravenous contrast injections can occur.
    • Understanding these responses is crucial for patient safety during diagnostic imaging.

    Purpose of the Study:

    • To monitor and report systemic blood pressure and pulse rate changes following rapid intravenous contrast material administration.
    • To correlate observed hemodynamic responses with clinically apparent adverse reactions.
    • To identify the incidence of significant hypotension during excretory urography.

    Main Methods:

    • Ninety-seven patients undergoing excretory urography were enrolled.
    • Systemic blood pressure and pulse rates were continuously monitored before and after contrast injection.

    Related Experiment Videos

  • Contrast material used was meglumine iothalamate (60%) at a dose of 1.5 ml/kg.
  • A Bard pressure monitor was employed for data acquisition.

    • Main Results:

    • Transient hypotension was the most frequent systemic response to rapid contrast infusion.
    • An increase in systemic blood pressure was strongly associated with nausea and vomiting.
    • Six patients (6%) exhibited significant hypotension (mean blood pressure < 60 mm Hg) without overt clinical manifestations.

    Conclusions:

    • Rapid intravenous contrast administration in excretory urography frequently induces transient hypotension.
    • Hemodynamic monitoring is essential to detect potential adverse events, even in asymptomatic patients.
    • Further research may elucidate the mechanisms behind contrast-induced hypotension and associated symptoms.