Acrokeratosis paraneoplastica (Bazex' syndrome)

Area of Science:

• Dermatology
• Oncology

Background:

• Acrokeratosis paraneoplastica, also known as Bazex' syndrome, is a rare paraneoplastic condition.
• It is characterized by specific skin and nail abnormalities.

Observation:

• A 63-year-old male presented with violaceous erythema and scaling on extremities, nose, and ears.
• Severe nail dystrophy was also noted.
• Initial investigations for malignancy were negative.

Findings:

• One year after symptom onset, an epidermoid carcinoma of the lung was diagnosed.
• This case illustrates a delayed but definitive association between Bazex' syndrome and lung cancer.

Implications:

• Early recognition of acrokeratosis paraneoplastica is crucial for cancer screening.
• This syndrome serves as a potential cutaneous marker for underlying lung malignancies.
• Further research into the pathogenesis of Bazex' syndrome may improve early cancer detection strategies.