[Electrolyte excretion following administration of various diuretics in healthy females]

The fractional water and electrolyte excretion was measured in healthy women after an intake of different thiazides in combination with spironolactone. The combination of 100 mg spironolactone either with 5 mg bendrofluazide or with 10 mg butizide increased significantly the diuresis over the whole day. The greatest effect was between the fourth and the eighth hour. The combination of 100 mg spironolactone with 20 mg furosemide augmented diuresis only in the first two hours. All tested drugs induced a significantly increased excretion of sodium, whereas potassium excretion did not change. Magnesium excretion correlated with sodium excretion.