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Opiate antagonists reverse the hypoactivity associated with systemic anaphylaxis in mice
Pharmacology, Biochemistry, and Behavior
|March 1, 1984
Summary
Systemic anaphylaxis causes hypoactivity in mice, which is reversed by central opiate antagonists like naloxone. Peripheral antagonists were ineffective, suggesting central opiate pathways mediate this anaphylactic shock response.
Area of Science:
- Neuroscience
- Immunology
- Pharmacology
Background:
- Systemic anaphylaxis in mice presents with significant hypoactivity.
- Opiate antagonists can reverse this hypoactivity, indicating a potential role for endogenous opioid systems.
Purpose of the Study:
- To investigate the role of central nervous system (CNS) opiate mechanisms in anaphylaxis-induced hypoactivity.
- To determine if peripherally acting opiate antagonists can reverse anaphylaxis-induced hypoactivity.
Main Methods:
- Mice experiencing systemic anaphylaxis were treated with naloxone or naltrexone (central opiate antagonists).
- The effects of naltrexone methyl bromide (a selective peripheral opiate antagonist) on anaphylaxis-induced hypoactivity were assessed.
Main Results:
- Naloxone and naltrexone effectively reversed the hypoactivity associated with systemic anaphylaxis.
- Naltrexone methyl bromide did not reverse the hypoactivity, despite being a potent peripheral opiate antagonist.
Conclusions:
- Central nervous system opiate mechanisms play a significant role in the hypoactivity observed during anaphylaxis.
- Endogenous opiates are implicated in the pathophysiological consequences of anaphylactic shock.