Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brain trace elements in Pick's disease.

W D Ehmann, M Alauddin, T I Hossain

    Annals of Neurology
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Management of Neglected Rupture of Tendoachilles with Long Gap by Flexor Hallucis Longus Tendon Transfer.

    Mymensingh medical journal : MMJ·2022
    Same author

    Clinical Outcome on Comminuted Femoral Shaft Fractures in Adults Treated by Minimally Invasive Plate Osteosynthesis (MIPO) with Locking Plate.

    Mymensingh medical journal : MMJ·2021
    Same author

    Clinical Outcome in Intra Articular Distal Humerus Fractures in Adults Treated with Different Hardware in a Tertiary Level Hospital of Bangladesh.

    Mymensingh medical journal : MMJ·2021
    Same author

    Correlates of functional capacity among centenarians.

    Journal of applied gerontology : the official journal of the Southern Gerontological Society·2014
    Same author

    Age group differences in positive and negative affect among oldest-old adults: findings from the Georgia Centenarian Study.

    International journal of aging & human development·2014
    Same author

    TGF-β1 induces EMT reprogramming of porcine bladder urothelial cells into collagen producing fibroblasts-like cells in a Smad2/Smad3-dependent manner.

    Journal of cell communication and signaling·2013
    Same journal

    AQP4 and MOG Characterize the Autoantibody Landscape of Checkpoint Blockade-Induced Optic Neuritis.

    Annals of neurology·2026
    Same journal

    Five Issues of Artificial Intelligence in Science: Sailing the Ship of Theseus.

    Annals of neurology·2026
    Same journal

    Reply to "Clinical Value of Aneurysm Wall Enhancement in Unruptured Intracranial Aneurysm".

    Annals of neurology·2026
    Same journal

    Clinical Value of Aneurysm Wall Enhancement in Unruptured Intracranial Aneurysm.

    Annals of neurology·2026
    Same journal

    Imaging of Neurovascular Compression in Thoracic Outlet Syndrome.

    Annals of neurology·2026
    Same journal

    Reply to "Methodological Challenges in Interpreting SAA-Defined Imaging Subgroups in Parkinson's Disease".

    Annals of neurology·2026
    See all related articles

    Trace element analysis in Pick's disease brains revealed significant changes in chlorine, iron, manganese, sodium, and phosphorus. This study did not support the hypothesis of elevated zinc in Pick's disease pathogenesis.

    Area of Science:

    • Neurochemistry
    • Trace Element Analysis
    • Neuropathology

    Background:

    • Pick's disease is a rare neurodegenerative disorder.
    • Understanding the biochemical alterations in affected brain tissue is crucial for elucidating disease mechanisms.

    Observation:

    • Postmortem brain tissue from two patients with Pick's disease was analyzed for trace element content using instrumental neutron activation analysis.
    • A comparison was made between patients with Pick's disease and control subjects.

    Findings:

    • Significant increases in chlorine, iron, manganese, sodium, and phosphorus were observed in the brains of patients with Pick's disease.
    • Significant decreases in chromium, cesium, rubidium, and selenium were noted.
    • The mean freeze-dried to wet-weight ratio was also decreased in patients with Pick's disease.

    Related Experiment Videos

  • Brain zinc content was not elevated, challenging the hypothesis of its role in Pick's disease pathogenesis.

    • Implications:

    • The observed alterations in trace element profiles may offer new insights into the pathophysiology of Pick's disease.
    • These findings suggest that zinc accumulation is unlikely to be a primary factor in the development of Pick's disease.
    • Further research into the role of specific trace elements could lead to novel diagnostic or therapeutic strategies.