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[Electrocardiogram changes in the rat by coenzyme A action]
Bollettino Della Societa Italiana Di Biologia Sperimentale
|February 28, 1984
Summary
Previous research showed coenzyme A lowers heart rate. This study found adenosine, a component of coenzyme A, is responsible for this bradycardia effect, not other constituents.
Area of Science:
- Biochemistry
- Pharmacology
- Cardiology
Context:
- Coenzyme A administered intravenously can cause a transient decrease in sinus rate.
- The specific component of coenzyme A responsible for this effect was previously unknown.
Purpose:
- To identify which component of coenzyme A induces bradycardia.
- To investigate the effects of pantothenic acid, cysteine, pantethein, and adenosine on sinus rate.
Summary:
- Experiments involved intravenous administration of pantothenic acid (200-400 mg/Kg), cysteine (40-80 mg/Kg), pantethein (40-100 mg/Kg), and adenosine (4-10 mg/Kg).
- Results indicated that adenosine is the component responsible for the observed bradycardia.
- Pantothenic acid, cysteine, and pantethein did not produce a similar effect on sinus rate.
Impact:
- Identifies adenosine as the active agent in coenzyme A causing bradycardia.
- Clarifies the pharmacological action of coenzyme A components.
- Provides insights into potential cardiovascular effects of adenosine and coenzyme A metabolism.