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Correction factors for determining body exposure from forearm percutaneous absorption data.

R H Guy, H I Maibach

    Journal of Applied Toxicology : JAT
    |February 1, 1984
    PubMed
    Summary

    Forearm skin absorption data may underestimate total body toxic exposure. Studies show significant variations in skin penetration across different body sites, suggesting forearm data alone can be inaccurate for risk assessment.

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    Area of Science:

    • Toxicology and Environmental Health
    • Dermatology and Cutaneous Science
    • Human Physiology and Anatomy

    Background:

    • Percutaneous absorption studies commonly rely on forearm data and area multiplication factors for toxic exposure evaluation.
    • Existing literature indicates significant variability in skin penetration rates across different anatomical locations.
    • This site-specific variation challenges the accuracy of using solely forearm data for predicting total body exposure.

    Purpose of the Study:

    • To evaluate the accuracy of using forearm percutaneous absorption data for estimating total body toxic exposure.
    • To develop correction factors accounting for anatomical site variations in skin penetration.
    • To assess exposure predictions for different age groups (adult, child, neonate) and localized exposure scenarios.

    Main Methods:

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    • Literature review of experimental data on cutaneous absorption rates as a function of anatomical position.
    • Utilization of accepted estimations for human body surface areas.
    • Calculation of correction factors for forearm penetration data and assessment of specific exposure examples.

    Main Results:

    • Demonstrated substantial site-specific variations in skin penetration, contradicting uniform absorption assumptions.
    • Calculated age-specific correction factors for adults, small children, and neonates.
    • Showed that forearm skin penetration data alone can underestimate total body exposure by a factor of two or more.

    Conclusions:

    • Forearm percutaneous absorption data alone is insufficient for accurate total body toxic exposure assessment.
    • Site-specific absorption data and appropriate correction factors are crucial for reliable risk evaluation.
    • The findings highlight the need for revised methodologies in toxic exposure assessments to account for anatomical variations.