[Pharmacokinetics of 35S-furosemide in experimental kidney failure in the rat]

Pharmacokinetics of 35S-Furosemide were determined after a single intravenous administration (2,5 mg/kg) in rats with experimental renal insufficiency due to figure in S-ligation of the kidney or subcutaneous injection of uranyl nitrate (10 mg/kg) in uninephrectomized animals. In the rat the pharmacokinetics of Furosemide obeyed to a two-compartment model. The distribution parameters were not markedly altered by renal insufficiency while the elimination ones were decreased proportionally to the renal impairment. Since these data are in close agreement with those observed in humans such an experimental study allows to predict the changes exhibited by patients with impaired renal function. Therefore the use of rats with renal insufficiency might be of value to design the safest protocol which has to be used for the pharmacokinetic study of drugs with low therapeutic index in patients with renal diseases.