[Kidney function in persons with disordered glucose tolerance and in patients with initial type I and II diabetes...

The renal function was investigated in 17 subjects with disordered glucose tolerance, in 14 patients with diabetes mellitus of the I type, persisted up to one year, and in 11 patients with primary diabetes mellitus of the II type. The renal secretory-excretory function (RSEF) and the effective renal circulation (ERC) were studied by means of radioisotopic technique, using 131I-hippuran. The patients were examined over a period of diabetes mellitus decompensation. The results obtained have shown no changes in the renal function of patients with decreased glucose tolerance, testifying to a significant role of obviously disturbed carbohydrate metabolism in the development of diabetic angionephropathy. In patients with diabetes mellitus of the I type the retained urine passage and ERC rise were observed, whereas in patients with the disease of the II type the decreased ERC and unchanged RSEF were seen. According to the data obtained it was concluded that the differences in the renal function of patients with diabetes mellitus of the I and II types are caused by various clinical courses.