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Ethionamide-induced goitrous hypothyroidism.

D Drucker, M C Eggo, I E Salit

    Annals of Internal Medicine
    |June 1, 1984
    PubMed
    Summary
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    Ethionamide, used for mycobacterial infections, can cause goitrous hypothyroidism in susceptible individuals. Thyroid function returned to normal after stopping the drug, indicating a reversible goitrogenic effect.

    Area of Science:

    • Endocrinology
    • Pharmacology

    Background:

    • Ethionamide is a medication used to treat atypical mycobacterial infections.
    • Hypothyroidism is a condition characterized by an underactive thyroid gland.

    Observation:

    • A patient receiving ethionamide developed goitrous hypothyroidism.
    • Thyroid function normalized five weeks after ethionamide discontinuation.

    Findings:

    • In vitro studies demonstrated ethionamide's inhibitory effect on iodine and technetium uptake by thyroid cells.
    • Ethionamide demonstrated goitrogenic properties at clinically relevant concentrations (10(-5) mol/L).

    Implications:

    • Ethionamide may act as a goitrogen in susceptible individuals.
    • Monitoring thyroid function in patients treated with ethionamide is recommended.

    Related Experiment Videos

  • This finding highlights a potential adverse drug reaction associated with ethionamide therapy.