Vitiligo treated with topical clobetasol propionate

Seventy-five patients with vitiligo were treated with intermittent topical applications of clobetasol propionate for varying times within a three-year period. The best results occurred in the facial lesions of Asian or black patients. Repigmentation of 90% to 100% was achieved in more than 80% of patients with vitiligo of the face and more than 40% of patients with vitiligo on other parts of the body. Progressive repigmentation continued even after the treatment stopped. Intermittent therapy helped to avoid the problems of adverse local effects from the use of potent adrenal steroids.