Idiopathic solitary granuloma of the uveal tract

We reviewed the clinical and histopathologic features of 11 cases of a distinctive solitary necrotizing granuloma of the uveal tract. No clinical or histopathologic cause for the lesion could be found in any case. The granulomas were located between the pars plana ciliaris and the equator and had an annular configuration. Uveal effusion and total retinal detachment were present in each eye. Uveitis was unilateral in all cases, and all patients were in otherwise good health. The morphologic characteristics of the solitary necrotizing granuloma suggest an infection, but the cause of this previously unreported entity remains to be determined.