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Sequential biochemical investigations in lepromatous leprosy
Leprosy in India
|April 1, 1978
Summary
Lepromatous leprosy patients show altered biochemical markers. Reactive phases exhibit low blood sugar and cholesterol, with changes in protein levels and liver enzymes, indicating disease activity.
Area of Science:
- Biochemistry
- Medical Microbiology
- Immunology
Background:
- Lepromatous leprosy is a chronic infectious disease affecting the skin and peripheral nerves.
- Understanding biochemical changes during different disease phases is crucial for management.
Purpose of the Study:
- To investigate sequential biochemical alterations in lepromatous leprosy patients.
- To correlate these changes with reactive and subsided disease phases.
Main Methods:
- Sequential biochemical investigations were performed on lepromatous leprosy patients.
- Analysis included blood sugar, serum cholesterol, thymol turbidity, albumin/globulin ratio, transaminases, and serum protein electrophoresis.
Main Results:
- The reactive phase showed low blood sugar and serum cholesterol.
- Increased thymol turbidity, decreased albumin/globulin ratio, and elevated transaminases were observed.
- Serum protein electrophoresis revealed increased alpha2-globulin and gamma-globulin, with decreased albumin in both phases.
Conclusions:
- Biochemical profiles of lepromatous leprosy patients change significantly between reactive and subsided phases.
- These alterations reflect underlying disease activity and potential organ involvement.