Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet size and age determine platelet function independently.

C B Thompson, J A Jakubowski, P G Quinn

    Blood
    |June 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Enhancing Brain Lesions during Acute Optic Neuritis and/or Longitudinally Extensive Transverse Myelitis May Portend a Higher Relapse Rate in Neuromyelitis Optica Spectrum Disorders.

    AJNR. American journal of neuroradiology·2017
    Same author

    Tract-Specific Diffusion Tensor Imaging in Cervical Spondylotic Myelopathy Before and After Decompressive Spinal Surgery: Preliminary Results.

    Clinical neuroradiology·2015
    Same author

    Adoption of electronic health records: a qualitative study of academic and private physicians and health administrators.

    Applied clinical informatics·2013
    Same author

    Epidemiology, outcomes, and mortality predictors of invasive mold infections among transplant recipients: a 10-year, single-center experience.

    Transplant infectious disease : an official journal of the Transplantation Society·2013
    Same author

    Rethinking the regulation of cellular metabolism.

    Cold Spring Harbor symposia on quantitative biology·2012
    Same author

    Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production.

    Oncogene·2011
    Same journal

    Fibrocytes drive JAK2V617F-mutated myelofibrosis: pitavastatin reverses marrow fibrosis and anemia.

    Blood·2026
    Same journal

    Identifying steroid-refractory aGVHD before it happens.

    Blood·2026
    Same journal

    ELISA-negative HIT: antibody recognition and relevance.

    Blood·2026
    Same journal

    EBV and immunodeficiency: the odd couple drawn to the brain.

    Blood·2026
    Same journal

    A bone to pick with ferric carboxymaltose.

    Blood·2026
    Same journal

    A step toward streamlining HIT diagnosis.

    Blood·2026
    See all related articles

    Younger platelets exhibit greater activity than older ones, with larger platelets showing faster aggregation. This study reveals platelet size and age independently influence platelet function.

    Area of Science:

    • Hematology
    • Cell Biology
    • Biophysics

    Background:

    • Platelet function is crucial for hemostasis and thrombosis.
    • The roles of platelet size and age in platelet function are not fully understood.
    • Investigating these factors can provide insights into platelet disorders.

    Purpose of the Study:

    • To investigate the interplay between platelet size and age in determining in vitro platelet function.
    • To elucidate the independent and combined effects of platelet size and age on platelet reactivity.
    • To quantify the functional differences between young and old platelets.

    Main Methods:

    • Baboon megakaryocytes were labeled with 75Se-methionine to track platelet age.
    • Platelet subpopulations were separated by size using counterflow centrifugation.

    Related Experiment Videos

  • Thrombin-induced platelet aggregation was measured to assess reactivity.
  • Radioactivity (75Se) in aggregated platelets quantified young platelet contribution.

    • Main Results:

    • Platelet aggregation rate was faster in larger platelet fractions compared to smaller ones, irrespective of age.
    • Younger platelets (day 2) showed higher incorporation of 75Se into aggregates than older platelets (day 9).
    • This age-dependent difference in activity was consistent across all platelet sizes.

    Conclusions:

    • Platelet size influences aggregation rate, with larger platelets being more reactive.
    • Platelet age significantly impacts platelet function, with younger platelets demonstrating heightened activity.
    • Both platelet size and age are independent determinants of platelet function, mediated through distinct mechanisms.