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Inhibition of synaptosomal 5-[3H]hydroxytryptamine uptake by endogenous factor(s) in human blood
FEBS Letters
|June 11, 1984
Abstract:
The inhibition of 5-[3H]hydroxytryptamine uptake into rat forebrain synaptosomes by human plasma extracts was studied. Highly potent, small (Mr less than 10 000), and heat stable factor(s) were found to inhibit 5-[3H]hydroxytryptamine uptake specifically, reversibly and in a non-competitive manner. The possible role of these factor(s) as endogenous modulators of serotonergic activity is discussed.

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