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Related Experiment Videos

Aromatization by splanchnic tissue in men.

C Longcope, K Sato, C McKay

    The Journal of Clinical Endocrinology and Metabolism
    |June 1, 1984
    PubMed
    Summary
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    This study measured aromatization in the splanchnic tissue, finding that it accounts for less than 4% of overall peripheral aromatization of androstenedione or testosterone in men.

    Area of Science:

    • Endocrinology
    • Metabolic studies

    Background:

    • Aromatization, the conversion of androgens to estrogens, is crucial for hormonal balance.
    • The contribution of splanchnic tissue to overall aromatization is not well-defined.

    Purpose of the Study:

    • To quantify the rate of aromatization occurring specifically within the splanchnic tissue.
    • To determine the splanchnic bed's contribution to peripheral aromatization of androgens.

    Main Methods:

    • Infusion of radiolabeled androstenedione/estrone and testosterone/estradiol in healthy men.
    • Collection of blood samples from the hepatic vein and aorta.
    • Analysis of radioactivity using chromatographic purification to determine splanchnic aromatization rates.

    Main Results:

    Related Experiment Videos

    • Splanchnic extraction values for androstenedione, testosterone, estrone, and estradiol were determined.
    • Mean splanchnic aromatization of androstenedione to estrone was 0.00086.
    • Mean splanchnic aromatization of testosterone to estradiol was 0.00059.

    Conclusions:

    • Splanchnic aromatization contributes minimally to the overall peripheral aromatization of androstenedione and testosterone.
    • The splanchnic bed is responsible for less than 4% of total peripheral aromatization.