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Clostridium difficile-associated diarrhoea.

R P Brettle, E Wallace

    The Journal of Infection
    |March 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Clostridium difficile is frequently found in patients with diarrhea, significantly more than in healthy individuals. Routine stool cultures should include C. difficile testing, as it is as common as Campylobacter infections.

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    Area of Science:

    • Medical Microbiology
    • Clinical Bacteriology
    • Infectious Diseases

    Background:

    • Clostridium difficile is an opportunistic pathogen causing antibiotic-associated diarrhea.
    • Routine laboratory identification of C. difficile is crucial for patient management.

    Purpose of the Study:

    • To determine the prevalence of Clostridium difficile in fecal specimens from patients with suspected gastroenteritis.
    • To compare C. difficile isolation rates in patients versus a control population.
    • To assess the need for routine C. difficile culturing in hospital laboratories.

    Main Methods:

    • Analysis of 3591 fecal specimens submitted to a routine bacteriology laboratory over one year.
    • Identification of C. difficile in 145 specimens (4%).
    • Comparison of isolation rates in 864 patients with suspected gastroenteritis (10.99%) against 318 controls (3.1%).

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    Main Results:

    • A statistically significant higher isolation rate of C. difficile in patients with diarrhea compared to controls.
    • C. difficile was isolated from 10.99% of patients investigated for gastroenteritis.
    • Isolation frequency of C. difficile was comparable to Campylobacter spp.

    Conclusions:

    • Routine bacteriology laboratories should include C. difficile cultures for fecal specimens.
    • C. difficile is a significant cause of infectious diarrhea in hospital settings.
    • While most cases are mild, 20% of patients may experience prolonged diarrhea requiring treatment.