Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease in bone density in young male guinea pigs fed high levels of ascorbic acid.

D L Bray, G M Briggs

    The Journal of Nutrition
    |May 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Folic acid in the prevention of abnormal feather pigmentation of chicks fed purified diets.

    Federation proceedings·2010
    Same author

    Perosis caused by feeding high levels of thiouracil.

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)·2010
    Same author

    Studies on the liberation of compounds in the folic acid group.

    The Journal of biological chemistry·2010
    Same author

    Influence of gelatin and tryptophane on nicotinic acid requirement of chicks.

    The Journal of biological chemistry·2010
    Same author

    Growth inhibitory action of amino acids in nicotinic acid-low diets for chicks.

    Federation proceedings·2010
    Same author

    The growth-promoting action of cellulose in purified diets for chicks.

    The Journal of nutrition·2010
    Same journal

    Considerations for Dietary Supplements After GLP-1RA Treatment: A Narrative Review.

    The Journal of nutrition·2026
    Same journal

    The apple(juice) doesn't fall far from the tree: Children's hydration mirrors their parent's.

    The Journal of nutrition·2026
    Same journal

    Microbial-derived polyphenol metabolites and the gut microbiota: A scoping review of clinical studies.

    The Journal of nutrition·2026
    Same journal

    Hesperidin as an Emerging Nutraceutical in Modern Health and Preventive Medicine: A Narrative Review.

    The Journal of nutrition·2026
    Same journal

    Short-Chain Fatty Acids in Livestock and Aquatic Animals: Metabolic Divergence, Physiological Functions, and Product Development.

    The Journal of nutrition·2026
    Same journal

    Immunomodulatory properties of choline and its dietary forms throughout the lifespan.

    The Journal of nutrition·2026
    See all related articles

    High oral intake of ascorbic acid in young guinea pigs led to decreased bone density and urinary hydroxyproline. Acidity, not vitamin activity, appears to be the primary factor, though other properties may contribute.

    Area of Science:

    • Biochemistry
    • Nutrition Science
    • Bone Metabolism

    Background:

    • Ascorbic acid (vitamin C) is essential for bone health.
    • High doses of ascorbic acid may impact bone metabolism.
    • Understanding the mechanism of action is crucial for nutritional guidelines.

    Purpose of the Study:

    • To investigate the effects of high oral ascorbic acid intake on bone metabolism in young guinea pigs.
    • To determine the mechanism behind these effects, distinguishing between acidity and vitamin activity.

    Main Methods:

    • Young guinea pigs were fed diets with 8.7% ascorbic acid for 6 weeks.
    • Control groups received 0.2% ascorbic acid.
    • Comparative analysis included bone density and urinary hydroxyproline levels.

    Related Experiment Videos

  • Experiments also tested salts of ascorbic acid, erythorbic acid, and free erythorbic acid.

    • Main Results:

    • High ascorbic acid intake significantly decreased bone density.
    • Urinary hydroxyproline levels were also reduced in the high-intake group.
    • No significant bone changes were observed when feeding salts of ascorbic acid, salts of erythorbic acid, or free erythorbic acid.

    Conclusions:

    • The acidity of ascorbic acid appears to play a role in decreasing bone density.
    • While acidity is implicated, other specific metabolic properties of ascorbic acid cannot be entirely ruled out.
    • Further research is needed to fully elucidate the complex mechanisms involved.