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The megacystis-megaureter syndrome.

K A Burbige, R L Lebowitz, A H Colodny

The Journal of Urology

|June 1, 1984

Summary

Megacystis-megaureter syndrome involves a large bladder and massive reflux. Antireflux surgery alone effectively treats this condition in children, preserving renal function.

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Area of Science:

Pediatric Urology
Radiology
Nephrology

Background:

Megacystis-megaureter syndrome is characterized by a large, thin-walled bladder and significant primary vesicoureteral reflux.
The condition involves continuous recycling of large urine volumes, leading to massively dilated ureters and bladder.

Observation:

29 children (1 day to 13 years) with megacystis-megaureter were treated.
74% of cases presented with urinary tract infections.
Children treated before 1975 were often misdiagnosed with bladder outlet obstruction, leading to inappropriate interventions and renal damage.

Findings:

15 children treated after 1975 with antireflux surgery alone showed stable renal function and minimal residual urine.
This indicates that correction of massive reflux is the primary therapeutic goal.

Implications:

Early and accurate diagnosis of megacystis-megaureter is crucial.
Antireflux surgery is the preferred treatment, avoiding interventions for presumed bladder outlet obstruction or bladder capacity reduction.
Effective management preserves long-term renal health in affected children.

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