Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cancer as a systemic disease.

G Zajicek

    Medical Hypotheses
    |May 1, 1978
    PubMed
    Summary

    Cancer is viewed as a local issue, but emerging theories suggest it

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Computerized extraction of the time dimension in histopathological sections.

    Applied optics·2010
    Same author

    Computer assisted physiologic monitoring and stability assessment in vascular surgical patients undergoing general anesthesia--preliminary data.

    Journal of clinical monitoring and computing·2003
    Same author

    Cancer and metaphysics.

    Medical hypotheses·2001
    Same author

    Turnover and migration of meibomian gland cells in rats' eyelids.

    Ophthalmic research·2001
    Same author

    Calcium supplements interact significantly with long-term diet while suppressing rectal epithelial proliferation of adenoma patients.

    Cancer·2001
    Same author

    Pernicious cachexia: a different view of cancer.

    Anticancer research·2000

    Area of Science:

    • Oncology
    • Systemic Diseases
    • Epidemiology

    Background:

    • Current medical understanding often views cancer as a strictly local phenomenon.
    • However, theories like immunological surveillance and protovirus-oncogene implicitly suggest cancer is a local manifestation of a systemic disease.
    • Epidemiological data further supports the systemic nature of cancer.

    Purpose of the Study:

    • To clarify the definition of a systemic disease.
    • To compare cancer's manifestation with that of arteriosclerosis, a known systemic disease.
    • To propose a new framework for understanding cancer as a systemic disease.

    Main Methods:

    • Comparative analysis of cancer and arteriosclerosis as systemic diseases.
    • Review of existing theories on cancer etiology (immunological surveillance, protovirus-oncogene).
    • Examination of epidemiological data related to cancer.

    Main Results:

    • Arteriosclerosis serves as a prototype systemic disease, presenting with local manifestations (e.g., myocardial infarction) that can lead to secondary systemic sequelae (e.g., congestive heart failure).
    • Cancer, like arteriosclerosis, is proposed to be a systemic disease manifesting locally (e.g., carcinoma, lymphoma, sarcoma).
    • These local cancer manifestations can subsequently lead to systemic sequelae, such as metastasis.

    Conclusions:

    • Cancer should be conceptualized as a systemic disease, not merely a local one.
    • The local manifestations of cancer are analogous to the local sequelae of arteriosclerosis.
    • Understanding cancer as a systemic disease provides a more comprehensive framework for its study and treatment, considering potential secondary systemic effects like metastasis.

    Related Experiment Videos