Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renal involvement in systemic lupus erythematosus.

N W Boyce, S R Holdsworth, N M Thomson

    The Medical Journal of Australia
    |June 23, 1984
    PubMed
    Summary

    This study on lupus nephritis found that prednisolone alone or with azathioprine offered similar 5-year survival rates (82%). Opportunistic infections were the main cause of death, highlighting treatment risks.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Incidence of chronic kidney disease among people with diabetes: a systematic review of observational studies.

    Diabetic medicine : a journal of the British Diabetic Association·2017
    Same author

    A robust route to enzymatically functional, hierarchically self-assembled peptide frameworks.

    Advanced materials (Deerfield Beach, Fla.)·2013
    Same author

    Diabetic kidney disease: act now or pay later.

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2010
    Same author

    A pathogenic role for JNK signaling in experimental anti-GBM glomerulonephritis.

    Kidney international·2007
    Same author

    Dysregulated growth factor gene expression is associated with tubulointerstitial apoptosis and renal dysfunction.

    Kidney international·2007
    Same author

    Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated mice.

    Kidney international·2005

    Area of Science:

    • Nephrology
    • Immunology
    • Rheumatology

    Background:

    • Lupus nephritis is a severe manifestation of systemic lupus erythematosus.
    • Accurate classification of lupus nephritis is crucial for prognosis and treatment.
    • Long-term outcomes and treatment efficacy in lupus nephritis require ongoing investigation.

    Purpose of the Study:

    • To review outcomes of lupus nephritis cases treated at Prince Henry's Hospital.
    • To evaluate the efficacy of prednisolone and prednisolone/azathioprine combination therapy.
    • To identify major causes of morbidity and mortality in lupus nephritis patients.

    Main Methods:

    • Retrospective review of 28 biopsy-proven lupus nephritis cases (1971-1982).
    • Histopathological classification using WHO criteria for lupus nephritis.
    • Analysis of treatment regimens (prednisolone alone vs. prednisolone/azathioprine) and patient survival.

    Main Results:

    • Class IV (diffuse proliferative) and Class IIb (mesangial proliferative) were the most common histological types.
    • Both treatment regimens achieved an 82% five-year survival rate with similar renal function preservation.
    • Opportunistic infections accounted for 60% of deaths, a significant treatment-related morbidity.

    Conclusions:

    • Prednisolone monotherapy or combination therapy with azathioprine yields satisfactory outcomes in lupus nephritis.
    • Immunosuppressive therapy, while effective, carries significant risks, primarily opportunistic infections.
    • Despite severe disease forms, treatment offers a reasonable prognosis, necessitating careful risk-benefit assessment.

    Related Experiment Videos