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Related Experiment Videos

A portable precision pumping system for chronic, programmed insulin infusion.

A M Albisser, W S Jackman, R Ferguson

    Medical Progress Through Technology
    |May 23, 1978
    PubMed
    Summary
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    A new insulin delivery system with a precision pump offers accurate, long-term intravenous therapy. This device has successfully reversed experimental diabetes in dogs, paving the way for human clinical trials.

    Area of Science:

    • Biomedical Engineering
    • Endocrinology

    Background:

    • Diabetes mellitus requires precise insulin management.
    • Existing insulin delivery systems may have limitations in long-term precision and control.

    Purpose of the Study:

    • To detail a novel insulin delivery system.
    • To evaluate the system's precision, longevity, and efficacy in a preclinical model.

    Main Methods:

    • Development of a 50 ml insulin reservoir coupled to a precision peristaltic pump.
    • Incorporation of a flow rate controller in a battery power pack allowing 128 flow rates (0-80 microliter/min).
    • Bench testing (30 days), extended life testing (11 months), and in vivo studies on dogs.

    Main Results:

    • The system demonstrated high precision (+/- 1.6% over 10 months) and low power consumption (60 mW at max rate).

    Related Experiment Videos

  • Preclinical trials showed successful long-term intravenous insulin therapy in dogs.
  • Experimental diabetes was reversed in 4 dogs for over 6 months using the system.

    • Conclusions:

    • The developed insulin delivery system is precise, reliable, and suitable for long-term use.
    • The system shows significant potential for managing diabetes mellitus.
    • The device is ready for long-term studies in hospitalized patients with diabetes mellitus.