[Two cases of giant condyloma with malignant degeneration]

We report two rare cases of giant condyloma with malignant degeneration. Case 1: A 70-year-old male noticed a small nodule on his glans penis 5 years ago that had recently grown larger and larger. After admission, the biopsy of the mass revealed giant condyloma with malignant degeneration. Partial amputation of the penis was performed. Meatoplasty was performed by Whisnant 's procedure. Case 2: A 49-year-old male had received exstirpation of the condyloma of the penis eleven years earlier. Local recurrence and exstirpation were repeated. In June 1981, the mass was diagnosed as giant condyloma. In December malignant degeneration was suspected. In 1982, radiation therapy failed to reduce the mass and it made an ulcer on the penis. Total amputation of the penis was performed. The pathological diagnosis was invasive keratinizing squamous cell carcinoma. Meatoplasty was performed, applying Toyoda 's ureterocutaneostomy and Abercrombie 's procedure. Though giant condyloma is pathologically benign, in many cases it is clinically indistinguishable from squamous cell carcinoma and may have a malignant potential like our cases. It may be concluded that giant condyloma should be treated as malignant and that partial or total penectomy may be the best treatment because conservative treatment including local excision is not effective.