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Reversible visual evoked potential abnormalities in vitamin E deficiency.

J A Messenheimer, R S Greenwood, M B Tennison

    Annals of Neurology
    |May 1, 1984
    PubMed
    Summary
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    Vitamin E deficiency in cystic fibrosis can cause neurological issues, including abnormal visual evoked potentials. Supplementation with vitamin E reversed these visual pathway abnormalities in a patient with ataxia and ophthalmoplegia.

    Area of Science:

    • Neurology
    • Nutritional Science
    • Ophthalmology

    Background:

    • Cystic fibrosis (CF) is a genetic disorder that can lead to various complications, including liver cirrhosis.
    • Neurological complications are increasingly recognized in CF patients, potentially linked to nutritional deficiencies.

    Observation:

    • A patient with CF and cirrhosis presented with a progressive neurological syndrome including ataxia, proximal weakness, and ophthalmoplegia.
    • Profound deficiencies in vitamins A, D, and E were identified.
    • Despite normal visual acuity and funduscopy, pattern reversal visual evoked potentials (VEP) showed abnormal P100 latencies.

    Findings:

    • Vitamin E administration over two months normalized the abnormal VEP findings.
    • This suggests a direct link between vitamin E deficiency and the observed visual pathway dysfunction.

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    Implications:

    • This case highlights the potential for reversible visual evoked potential abnormalities in visually asymptomatic patients with vitamin E deficiency.
    • It underscores the importance of monitoring and managing vitamin deficiencies in patients with cystic fibrosis and cirrhosis.
    • Early detection and treatment of vitamin E deficiency may prevent or reverse neurological and visual pathway damage.