Effect of plasma proteins on the sieving spectra of hemofilters

qoffxture of neutral maltodextrins with a continuous molecular weight distribution from 340 to 120,000 daltons has been used alone or in the presence of plasma to determine solute rejection by four hemofilters and the effect of plasma on such rejection. High pressure liquid chromatographic analyses were utilized to establish concentration ratios of feed and filtrate solutions over a wide molecular weight range. At equal transmembrane velocities, the boundary layer-corrected rejection of each hemofilter was determined as a function of molecular weight. The presence of plasma increased rejection by the Amicon Diafilter 30, the Hospal RP-6, and the Gambro FH202 hemofilters , but the Fresenius D-6 was virtually unaffected.