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Updated: Aug 11, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Published on: March 14, 2017

The sickle cell trait in relation to the training and assignment of duties in the armed forces: II. Aseptic splenic

L W Diggs

    Aviation, Space, and Environmental Medicine
    |April 1, 1984
    PubMed

    Well-documented information gleaned from the world's literature reveals that in vivo sickling of erythrocytes and vascular occlusive lesions involving the spleen have occurred in individuals with the sickle cell trait (SCT) while flying in unpressurized airplanes or when exposed to hypoxic environments in mountains at intermediate altitudes. The clinical and anatomical manifestations of splenic infarcts are described. Individuals without the trait do not develop splenic infarcts during or following exposure to ambient hypoxia.

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