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Mast cells in cluster headache. Ultrastructure, release pattern and possible pathogenetic significance
Cephalalgia : an International Journal of Headache
|June 1, 1984
Summary
Cluster headache may involve histamine release from skin mast cells, indicated by their secretory changes between attacks. This suggests mast cells play a role in cluster headache pain initiation.
Area of Science:
- Neurology
- Immunology
- Cell Biology
Background:
- Cluster headache etiology and pathogenesis are poorly understood.
- Histamine release from mast cells is a potential trigger for cluster headache pain.
- Mast cells are immune cells involved in inflammatory responses.
Purpose of the Study:
- To investigate the ultrastructural characteristics of cutaneous mast cells in cluster headache patients.
- To explore the potential role of mast cells in cluster headache pathogenesis.
Main Methods:
- Skin biopsies were obtained from the painful region of cluster headache patients between attacks.
- Ultrastructural analysis of mast cells was performed using electron microscopy.
Main Results:
- Mast cells exhibited signs of degranulation, including swollen granules, decreased density zones, membrane-bound vesicles, and granular fusion.
- These ultrastructural changes are consistent with a secretory pattern.
Conclusions:
- Cutaneous mast cells show signs of active secretion between cluster headache attacks.
- Mast cell activation, possibly via antidromic-reflex mechanisms, may contribute to cluster headache pain.