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Related Experiment Videos

Aqueous humor catecholamines.

R L Cooper, I J Constable, L Davidson

    Current Eye Research
    |June 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Catecholamines like norepinephrine, epinephrine, and dopamine were identified in human and monkey aqueous humor for the first time. Dopamine in monkey eyes may originate from structures other than the iris.

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    Area of Science:

    • Ophthalmology
    • Neuroscience
    • Pharmacology

    Background:

    • Catecholamines, including norepinephrine (NE), epinephrine (E), and dopamine (DA), are crucial neurotransmitters.
    • Their presence and role in the anterior segment of the eye, particularly in aqueous humor, are not well-established.

    Purpose of the Study:

    • To detect and quantify catecholamine levels in human aqueous humor under general anesthesia.
    • To measure catecholamine concentrations in monkey aqueous humor and investigate the origin of dopamine.

    Main Methods:

    • Assay of catecholamine levels (NE, E, DA) in aqueous humor and plasma of human subjects.
    • Measurement of catecholamine levels in monkey aqueous humor before and after iridectomy.
    • Utilized ketamine anesthesia for monkeys, known to inhibit catecholamine uptake.

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    Main Results:

    • Norepinephrine, epinephrine, and dopamine were detected in human aqueous humor.
    • Monkey aqueous humor showed significant levels of NE and DA, with DA levels unaffected by iridectomy.
    • Plasma catecholamine levels in humans were also measured for comparison.

    Conclusions:

    • Suggests potential production of dopamine in the eye from structures other than the iris, possibly ciliary body or retina.
    • Postulates the presence of dopaminergic neurons and receptors in the anterior segment of the eye.
    • Highlights the potential influence of anesthetic agents on measured catecholamine levels.