Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chelation of cadmium.

O Andersen

    Environmental Health Perspectives
    |March 1, 1984
    PubMed
    Summary

    Cadmium toxicity depends on chelation reactions, with metallothionein (MT) binding cadmium effectively in vivo. Chelating agents significantly alter cadmium

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Appetite stimulation with cannabis-based medicine and methods for assessment of glomerular filtration in older patients with medical illness: A study protocol.

    Basic & clinical pharmacology & toxicology·2023
    Same author

    Effectiveness of first generation disease-modifying therapy to prevent conversion to secondary progressive multiple sclerosis.

    Multiple sclerosis and related disorders·2022
    Same author

    Short-term prediction of secondary progression in a sliding window: A test of a predicting algorithm in a validation cohort.

    Multiple sclerosis journal - experimental, translational and clinical·2022
    Same author

    Epstein-Barr virus infection after adolescence and human herpesvirus 6A as risk factors for multiple sclerosis.

    European journal of neurology·2020
    Same author

    Neurofilament light protein levels in cerebrospinal fluid predict long-term disability of Guillain-Barré syndrome: A pilot study.

    Acta neurologica Scandinavica·2018
    Same author

    Preface.

    Acta neurologica Scandinavica·2017

    Area of Science:

    • Environmental Chemistry
    • Toxicology
    • Biochemistry

    Background:

    • Cadmium (Cd2+) toxicity is mediated by its interactions with biological ligands and chelating agents.
    • Cd2+ exhibits unique coordination chemistry, forming stable complexes with soft donor atoms, particularly sulfur.
    • The ion's polarizability and varied coordination geometries influence its biological interactions.

    Purpose of the Study:

    • To elucidate the role of chelation reactions in cadmium toxicity and distribution.
    • To investigate the binding characteristics and stability of cadmium complexes with various ligands.
    • To understand the influence of chelating agents on cadmium's in vivo behavior and toxicity.

    Main Methods:

    • Analysis of cadmium coordination chemistry and complex stability.
    • In vivo studies tracking cadmium distribution and binding to proteins like metallothionein (MT) and serum albumin.
    • Assessment of the impact of chelating agents (e.g., NTA, EDTA, STPP, CYS, GSH, BAL) on cadmium uptake and toxicity.

    Main Results:

    • In vivo, Cd2+ rapidly binds to metallothionein (MT), forming stable Cd-MT complexes that accumulate in the liver and kidney.
    • Gastrointestinal (GI) uptake of Cd2+ is not influenced by MT induction, suggesting endogenous MT is not involved in absorption.
    • Chelation with EDTA or BAL reduces cadmium uptake and acute toxicity, while NTA or STPP can enhance toxicity.

    Conclusions:

    • Metallothionein plays a crucial role in sequestering cadmium in vivo, influencing its distribution and toxicity.
    • The route of administration and the specific chelating agent significantly impact cadmium's toxicological profile.
    • Understanding cadmium's chelation chemistry is vital for predicting and mitigating its health effects.

    Related Experiment Videos