Age influence on D-glucose absorption depending on sodium concentration in the lumen of rat small intestine

The influence of decreased sodium concentration on D-Glucose jejunal and ileal absorption has been investigated in rats of three groups of different ages: 21-23 days, 2-3 months and 18 months old, using a perfusion system in vivo. In all the cases studied there was a decrease of D-Glucose absorption with reduced sodium concentrations. The ileum of 21-23 days old animals showed the greatest inhibition of D-Glucose absorption when sodium was substituted partially or totally by Tris-HCl.