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Spontaneous plasma exchange by gravity.

S Landini, U Coli, S Lucatello

The International Journal of Artificial Organs

|May 1, 1984

Summary

Researchers simplified spontaneous plasmapheresis using a single venous puncture and gravity filtration. This method allows for plasma separation and reinfusion of packed red cells with fresh frozen plasma or plasma substitutes.

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Area of Science:

Medical Devices
Cardiovascular System
Blood Filtration

Background:

Conventional plasmapheresis often requires complex setups.
Lysagth et al. previously reported a simplified model using an arteriovenous shunt and a plasmafilter.

Purpose of the Study:

To further simplify the apparatus for spontaneous plasmapheresis.
To develop a method using a single venous puncture for plasma separation.

Main Methods:

A simplified apparatus was designed using a single venous puncture.
Gravity was utilized to generate sufficient transmembrane pressure for plasma separation.
Packed red cells were reinfused after passing through the filter with fresh frozen plasma or plasma substitutes.

Main Results:

Related Experiment Videos

The simplified apparatus successfully achieved plasma separation via gravity.
The system allowed for efficient reinfusion of packed red cells with plasma components.

Conclusions:

A further simplified model of spontaneous plasmapheresis is feasible using a single venous puncture.
This technique offers a potentially less invasive approach to plasma separation and blood component management.