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Some factors that influence prolonged interfacial continuity.

C W Hall, P A Cox, S R McFarland

    Journal of Biomedical Materials Research
    |April 1, 1984
    PubMed
    Summary
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    Achieving long-term, infection-free percutaneous implants requires understanding and addressing failure mechanisms. Key challenges include managing extrinsic and intrinsic forces that damage the critical skin-implant interface.

    Area of Science:

    • Biomaterials Science
    • Tissue Engineering
    • Infection Control

    Background:

    • Percutaneous implants are crucial for long-term functional devices, but prolonged uninfected use remains elusive.
    • Failure mechanisms at the skin-implant interface are not fully understood, hindering successful long-term implantation.
    • Maintaining an intact skin-implant interface is vital to prevent microbial invasion and implant failure.

    Purpose of the Study:

    • To identify and elucidate the critical failure mechanisms associated with percutaneous implants.
    • To highlight the importance of the skin-implant interface integrity for prolonged implant functionality.
    • To underscore the need for further research into preventing implant-related infections and complications.

    Main Methods:

    • Review and analysis of existing literature on percutaneous implant failures.

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  • Categorization of failure mechanisms into extrinsic and intrinsic forces.
  • Examination of the biological response at the skin-implant interface, including epithelial migration and scar tissue formation.

    • Main Results:

    • Identified extrinsic forces (external environment) and intrinsic forces (biological responses) as primary causes of skin-implant interface failure.
    • Highlighted the role of shearing and tearing forces in compromising the integument.
    • Emphasized that compromised skin-implant interface leads to microbial invasion and necessitates implant removal.

    Conclusions:

    • Successful long-term percutaneous implantation hinges on addressing the complex interplay of mechanical forces and biological responses at the skin-implant interface.
    • Further research is required to develop strategies mitigating extrinsic and intrinsic forces to ensure implant survival and prevent infection.
    • Preventing integument compromise is paramount for the continued function and retention of percutaneous implants.