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Canine postradiation plasma glucose variations.

L G Cockerham, S A Simpson, T F Doyle

    Life Sciences
    |June 25, 1984
    PubMed
    Summary
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    Exposure to gamma radiation causes hypoglycemia in canines, characterized by a significant decrease in plasma glucose levels concurrent with radiation-induced hypotension. This suggests impaired hepatic gluconeogenesis following radiation exposure.

    Area of Science:

    • Radiation Biology
    • Physiology
    • Endocrinology

    Background:

    • Endotoxic or septic shock in canines is associated with hypoglycemia.
    • Canine exposure to supralethal gamma radiation induces acute systemic hypotension.

    Purpose of the Study:

    • To investigate the development of hypoglycemia in canines experiencing radiation-induced hypotension.
    • To determine the relationship between gamma radiation exposure and plasma glucose levels in canines.

    Main Methods:

    • Systemic arterial mean blood pressure (MBP) was measured using a femoral arterial catheter.
    • Plasma glucose levels were determined from the abdominal aorta and hepatic portal vein using a Beckman Glucose Analyzer.
    • Measurements were taken for one hour pre- and post-exposure to 100 Gy whole-body gamma radiation or sham radiation.

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    Main Results:

    • Canines exposed to gamma radiation exhibited a significant decrease in plasma glucose levels.
    • Hypoglycemia was observed concurrently with postradiation hypotension in both systemic and portal circulation.
    • Radiated animals showed a sharp decline in arterial glucose levels, reaching 20% below baseline by one hour postradiation.

    Conclusions:

    • Gamma radiation exposure in canines leads to significant postradiation hypoglycemia.
    • The findings suggest impaired hepatic gluconeogenesis as the cause of radiation-induced hypoglycemia.
    • Hypoglycemia is a concurrent effect of radiation-induced hypotension in canines.