[Radiosensitivity of stromal mechanocytes in human bone marrow and spleen]

The monolayer cultivation of the bone marrow and spleen from patients with Hodgkin's disease was done. The content of stromal precursor cells (CFU-F) varies significantly in the human spleen (1.2-26.4 per each 10(6) incubated in the culture of nucleated cells) and is approximately one order lower than in the bone marrow (2.1-53.8 per 10(5) myelokaryocytes). During exposure to 60Co gamma-rays the values of a mean lethal cell dose (D0) for splenic CFU-F proved to be higher (2.03 +/- 0.17 Gy) than those for CFU-F from the bone marrow (1.49 +/- 0.12 Gy).